Program

Session 1: PolyP and the Global Phosphorus Cycle

Moderators: Sidney Omelon (& to be named)

Time	Speaker	Institution	Topic
12:00	Check-in (for badges, etc.) opens at Kahn Auditorium
1:45	Opening remarks from the organizing committee
2:00 – 2:40	Thomas Kornberg	UCSF, USA	Keynote Address: “The First Family of Inorganic Polyphosphates”
2:40 – 3:10	Julia Diaz	UCSD, USA	“How Marine Polyphosphate Shapes Ocean Health and Fertility”
3:10 – 3:40	Ludmilla Aristilde	Northwestern University, USA	“Selectivity in Enzymatic Phosphorus Recycling with Fungal and Plant Phosphatases”
3:40	BREAK
4:15 – 4:30	Xingyu Yang	Hong Kong University of Science and Technology	Brief talk: “Unveiling the Role of Planktonic Polyphosphate in Aquatic Phosphorus Cycling with Novel Quantification”
4:30 – 5:00	Alison Baker	U. of Leeds, UK	“Polyphosphate Dynamics in Microalgae”
5:00 – 5:30	Lars Blank	RWT Aachen, Germany	“Contributing to a Sustainable P Future by PolyP Hyperaccumulation”

Moderators: Stephanie Smith & Blanca Lázaro

Time	Speaker	Institution	Topic
9:00 – 9:30	Brigitte Van Zundert	Andrés Bello University, Chile	“Inorganic Polyphosphate: from Basic Research to Diagnostic and Therapeutic Opportunities in ALS/FTD”
9:30 – 10:00	Ursula Jakob	U. Michigan, USA	“Role of Polyphosphate in Phase Separation”
10:00 – 10:30	Toshikazu Shiba	Regenetiss, Japan	“Basic Properties of Size Fractionated PolyP (EX-polyP) and its applications”
10:30 – 10:45	Mayara Bertolini	University of Georgia	Brief talk: “Essential Roles of Vacuolar Transporter Chaperones 1 and 4 in Polyphosphate Metabolism and T. cruzi Infectivity”
10:45 – 11:00	Pavithra Mahadevan	University of Michigan	Brief talk: “Polyphosphates as Modulators of Tau Aggregation and Propagation in Alzheimer’s Disease”
11:00	BREAK
11:30 – 12:00	Markus Bosmann	Boston University, USA	“Bacterial Polyphosphates in Innate and Adaptive Immunity”
12:00 – 12:30	Zongchao Jia	Queen’s University, Canada	“Modification of Histidine- and Lysine-Repeat Proteins by Polyphosphate”
12:30 – 1:00	Lunch
1:00 – 2:30	Poster session 1		Odd-numbered posters will be presented in this session

Moderators: Ursula Jakob & Sradha Bhatt

Time	Speaker	Institution	Topic
2:30 – 2:45	Renata Torres da Costa	Rutgers University	Brief talk: “Role of mitochondrial inorganic polyphosphate in mitophagy signaling and mitochondrial function in ischemic stroke”
2:45-3:00	Upendar Singh	Cleveland Clinic Cancer Institute	Brief talk: “Cell-endogenous tissue non-specific alkaline phosphatase activity facilitates polyphosphate-driven energy-intensive functions in platelets and cancer cells”
3:00 – 3:30	Andrea Ashford-Hicks & Damien Kudela	Cayuga Biotech, USA	“The potential of CAY001 (PolyP-SNP complex) to address life-threatening hemorrhage.”
3:30	BREAK
4:00 – 4:30	Jay Kizhakkedathu	U. of British Columbia, Canada	“Charge Switching Polycations as Polyphosphate Inhibitors”
4:30 – 5:00	Thomas Renné	University Medical Center Hamburg (UKE)	“Polyphosphate/Factor XII-Driven Coagulation Traps Bacterial Infection”

Moderators: Marien Solesio & Giuliano Kullik

Time	Speaker	Institution	Topic
9:00 – 9:30	Evgeny Pavlov	New York University, USA	“Inorganic Polyphosphate and Mitochondrial Permeability Transition”
9:30 – 10:00	Marien Solesio	Rutgers University, USA	“Inorganic Polyphosphate, AMPK, and Mitochondrial Physiology”
10:00 – 10:30	Rashna Bhandari	Centre for DNA Fingerprinting and Diagnostics (CDFD), India	“Organellar Polyphosphate in Mammalian Cells”
10:30 – 10:45	Zhiyun Yang	Queen’s University	Brief talk: “Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression”
10:45	BREAK
11:30 – 12:00	Josep Clotet	UIC Barcelona, Spain	“Polyphosphate: A Multitasker in Mammalian Cell Nuclei”
12:00 – 12:30	Felix Ruiz	University of Cádiz, Spain	“Inorganic polyphosphate levels are increased in the brain of diabetic mice”
12:30 – 1:00	Lunch
1:00 – 2:30	Poster session 2		Even-numbered posters will be presented in this session

Moderators: Henning Jessen & Guizhen Liu

Time	Speaker	Institution	Topic
2:30 – 3:00	Christopher Cummins	MIT, USA	“Synthesis and Applications of Oligophosphate Constructs”
3:00 – 3:30	Jennifer Andexer	University of Freiburg, Germany	“Using Polyphosphate for Cofactor Regeneration and Synthesis”
3:30	BREAK
4:00 – 4:15	Sandra Moser	University of Freiburg	Brief talk: “A Screening Approach Unveils an Unknown Mn2+-dependent Endopolyphosphatase Activity in Yeast”
4:15-4:30	Sunayana Sarkar	Tata Institute of Fundamental Research	Brief talk: “Development of tools to study biological functions of polyphosphate using Drosophila”
4:30 – 4:45	Benita Kröger	UKE – Hamburg	Brief talk: “Intracellular polyP degradation by ectopic polyphosphatase expression regulates T-cell responses”
4:45 – 5:00	Julius Narh	Illinois State University	Brief talk: “Investigating the protective role of polyphosphate during antibiotic-induced membrane stress”

Thursday Evening — Dinner at 6:00 pm for workshop participants who purchased a ticket (Location: Venue by 4M, Ann Arbor)

Moderators: Jim Morrissey & Chris Hamm

Time	Speaker	Institution	Topic
9:00 – 9:30	Dorothea Fiedler	Leibniz-FMP, Germany	“Pyrophosphorylation and Oligophosphorylation of Proteins”
9:30 – 10:00	Richard Gomer	Texas A&M University, USA	“Chemorepulsion from Extracellular Polyphosphate”
10:00 – 10:30	Michael Downey	University of Ottawa, Canada	“Systems Biology of Polyphosphate Metabolism”
10:30 – 11:00	Andreas Mayer	U. of Lausanne, Switzerland	“Strategies for PolyP and Phosphate Homeostasis from Yeast to Human Cells”
11:00	BREAK
11:30 – 12:00	Jan-Ulrik Dahl	Illinois State University	“The role of polyphosphate for the interaction between two major opportunistic pathogens”
12:00-12:15	Akash Rai	University of Michigan	Brief talk: “The role of polyphosphate in migration and metastasis”
12:15 – 1:30	Lunch

Michael Gray & Constanza Torres-Paris

Time	Speaker	Institution	Topic
1:30-2:00	Lisa Racki	Scripps Res. Institute, USA	“Polyphosphate Condensates and Chromatin in Pseudomonas aeruginosa”
2:00-2:30	Michael Gray	U. Alabama Birmingham, USA	“New Insights into Regulation of Polyphosphate Synthesis in Bacteria”
2:30-3:00	Hans-Georg Koch	University of Freiburg, Germany	“A Universally Conserved ATPase Controls Polyphosphate and Alarmone synthesis in E. coli”
3:00-3:30	BREAK
3:30-4:00	Gabriel Schaaf	University of Bonn, Germany	“Elucidating PolyP Synthesis in the Arbuscular Mycorrhizal Fungus Rhizophagus irregularis by a Synthetic Biology Approach”
4:00	Group discussion/planning for the next polyP conference